RELATIONSHIP BETWEEN HIGH-RISK AND HPV INFECTION CONGRESSED CANCER SUPPLY IN VIETNAM

– HPV infection is most common in sexually transmitted infections in many countries around the world- The most recent study showed that about 42.5% of women have vaginal HPV infection and about 7% have HPVoral- HPV infection of high-risk types is a major cause of cervical cancer- There are> 100 types of HPV, 30- 40 types of sexually transmitted. The 12 types of high-risk cervical mucosal changes that have been shown to cause cervical cancer are: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59- There is currently evidence of the role of both C. trachomatis and herpes simplex viruses as favorable factors in the pathology of HPV infection in relation to cervical neoplasia.- There are still very few studies in Vietnam analyzing the risk of HPV infection and cervical cancer.- So we implemented the project: “RELATIONSHIP BETWEEN HIGH-RISK HPV INFECTION AND CANCER CANCER IN VIETNAM

Research Methods

Subjects of the study: Selecting 100 patients diagnosed with cervical cancer confirmed by cytology and 100 women with normal cytological test results as the control group at K Hospital. The study in the control group and the control group was matched by age to ensure that the study subjects in the two groups were quite similar in age.

Research Methods

+ Design a case-control study to test the association between HPV infection and cervical cancer.

+ Cervical specimens are taken with a special brush and stored in a sterile 2% SDS vial.

+ Each sample is run in parallel PCR using the following primers: GP5 + / GP6 + general primers and targeted primers for HPV types 16, 18, 31, 33, 35, 39, 45, 51 , 52, 56, 58 and 59

Research results

Table 1: Relationship between HPV infection and cervical cancer

HPVKCTCIs notKCTCOR95%CI
HPV (+)912495,4104,26 – 2354,30
HPV (-)9981

There is a strong association between HPV infection and cervical cancer. Patients with HPV infection have a 495.4 times higher risk of cervical cancer than those without HPV. The difference is statistically significant.

Table 2. Distribution of HPV types in 91 cervical cancer patients

Type HPVAmountRatio%
HPV 633,0
HPV 111212,0
HPV 164545,0
HPV 181919,0
HPV 3333,0
HPV 3511,0
HPV 5211,0
HPV 5822,0
HPV 6 + 1111,0
HPV 16 + 1811,0
HPV 16 + 3311,0
HPV 18 + 5111,0

+ Out of 100 cervical cancer patients, there are 91 patients with HPV infection (accounting for 91%). Up to 46% of cervical cancer patients are infected with HPV type 16 and 19% with type 18 infection.

+ The proportion of cervical cancer patients with HPV type 11 infection accounts for 12%. Other types of HPV such as 6, 33 and 58 are also present among cervical cancer patients at the rate of 2-3%.

+ The rate of co-infection with 2 types of HPV in the same patient is not high (only 5%).

Table 3. Relationship between HPV type 16 infection and cervical cancer

Type HPVKCTCIs not

KCTC

OR95%CI
HPV 16 (+)47243,510,16-185,99
HPV 16 (-)53981

The table above shows a very close association between HPV type 16 infection and cervical cancer. People with HPV type 16 are 43.5 times more likely to get cervical cancer than people who are not infected with HPV.

The difference is statistically significant.

Table 4. Relationship between HPV type 18 infection and cervical cancer

Type HPVKCTCIs not

KCTC

PYates
HPV 18 (+)210p<0,0001
HPV 18 (-)79100

The table above shows a very strong association between HPV type 18 infection and cervical cancer. People with HPV type 18 infection are many times more likely than those who are not infected with HPV. The difference is statistically significant

Discuss

– There is a close relationship between HPV infection and cervical cancer.

– People with HPV have a 495.4 times higher risk of getting cervical cancer than people without HPV. Researchers at the Lyon International Cancer Research Institute have listed 12 types of HPV that have been shown to be high risk factors for cervical cancer, namely HPV types 16, 18, 31, 33, 35, 39 45, 51, 52, 56, 58, and 59

+ Types of HPV 16 and 18 are present in more than 70% of cervical cancer.

+ Out of 100 cervical cancer patients, there are 91 patients with HPV infection (accounting for 91%). Up to 46% of cervical cancer patients are infected with HPV type 16 and 19% are infected with type 18.

+ The percentage of cervical cancer patients infected with HPV type 11 accounts for 12%. Other types of HPV such as 6, 33 and 58 are also present among cervical cancer patients with the rate of 2-3%

+ The rate of co-infection with 2 types of HPV in a patient is not high (only 5%) Our study is consistent with those of Schiffman, Munoz et al. + The authors concluded that cervical cancer was caused by HPV infection, especially in types 16 and 18, which causes about 70% of cervical cancer cases.

+ In an international study of 1545 cases of cervical cancer, the association between HPV DNA and cervical cancer was found to have a relative risk of 83.3 times. Types HPV 16, 18, 31 and 45 are the most commonly detected types in both the control and control groups Conclude + Research has shown a close relationship between HPV infection and cervical cancer, especially between HPV types 16, 18 and cervical cancer.

+ The prevalence of HPV / cervical cancer patients is high, accounting for 91% (46% infected with HPV type 16 and 19% infected with type 18, type 11 accounting for 12%, HPV types: 6, 33, 58 accounting for 2-3%.

+ The rate of co-infection with 2 types of HPV in the same patient is not high (5%).

 

 

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